Publications | Chang Lu Lab

Representative Papers

(# denotes equal contribution, * denotes corresponding authors)

Figure from the 2025 Nature Communications psilocybin paper

Sex-specific role of the 5-HT2A receptor in psilocybin-induced extinction of opioid reward

Nature Communications 2025

Jaster, A. M., Hadlock, T. M.#, Buzzi, B.#, Maltman, J. L., Silva, G. M., Saha, S., Koseli, E., Pondelick, A. M., Thakur, N., Zhang, X., Li, G., Ledesma-Corvi, S., Moore, K. N., Peterson, H. R., Fujita, B., Zylko, A. L., Lewis, M. R., Poklis, J. L., Halquist, M. S., Wolstenholme, J. T., Selley, D. E., Hamilton, P. J., Lu, C.*, Damaj, M. I.*, Gonzalez-Maeso, J.* Nature Communications 16 (2025) 10206.

Figure from the 2024 Cell Reports Methods epigenomic tomography paper

Epigenomic tomography for probing spatially defined chromatin state in the brain

Cell Reports Methods 2024

Liu, Z.#, Deng, C.#, Zhou, Z., Xiao, Y., Jiang, S., Zhu, B., Naler, L., Jia, X., Yao, D., Lu, C.* Cell Reports Methods 4 (2024) 100738.

Figure from the 2024 eLife antipsychotic epigenomics paper

Antipsychotic-induced epigenomic reorganization in frontal cortex of individuals with schizophrenia

eLife 2024

Zhu, B.#, Ainsworth, R. J.#, Wang, Z., Liu, Z., Sierra, S., Deng, C., Callado, L. F., Meana, J. J., Wang, W.*, Lu, C.*, Gonzalez-Maeso, J.* eLife 12 (2024) RP92393.

Figure from the 2023 Nature Communications droplet-based bisulfite sequencing paper

Droplet-based bisulfite sequencing for high-throughput profiling of single-cell DNA methylomes

Nature Communications 2023

Zhang, Q., Ma, S., Liu, Z., Zhu, B., Zhou, Z., Li, G., Meana, J., Gonzalez-Maeso, J., Lu, C.* Nature Communications 14 (2023) 4672.

Figure from the 2021 Cell Reports psychedelic paper

Prolonged epigenomic and synaptic plasticity alterations following single exposure to a psychedelic in mice

Cell Reports 2021

de la Fuente Revenga, M., Zhu, B.#, Guevara, C. A.#, Naler, L. B., Saunders, J. M., Zhou, Z., Toneatti, R., Sierra, S., Wolstenholme, J. T., Beardsley, P. M., Huntley, G. W., Lu, C.*, Gonzalez-Maeso, J.* Cell Reports 37 (2021) 109836.

Figure from the 2019 Nature Protocols MOWChIP-seq paper

MOWChIP-seq for low-input and multiplexed profiling of genome-wide histone modifications

Nature Protocols 2019

Zhu, B.#, Hsieh, Y.-P.#, Murphy, T. W., Zhang, Q., Naler, L. B., Lu, C.* Nature Protocols 14 (2019) 3366-3394.

Figure from the 2018 Science Advances epigenomic variation paper

Low-input and multiplexed microfluidic assay reveals epigenomic variation across cerebellum and prefrontal cortex

Science Advances 2018

Ma, S., Hsieh, Y.-P., Ma, J., Lu, C.* Science Advances 4 (2018) eaar8187.

Figure from the 2018 Nature Biomedical Engineering brain methylomes paper

Cell-type-specific brain methylomes profiled via ultralow-input microfluidics

Nature Biomedical Engineering 2018

Ma, S., de la Fuente Revenga, M., Sun, Z., Sun, C., Murphy, T. W., Xie, H., Gonzalez-Maeso, J., Lu, C.* Nature Biomedical Engineering 2 (2018) 183-194.

Figure from the 2015 Nature Methods microfluidic device paper

A microfluidic device for epigenomic profiling using 100 cells

Nature Methods 2015

Cao, Z.#, Chen, C.#, He, B., Tan, K.*, Lu, C.* Nature Methods 12 (2015) 959-962.

All Publications

(# denotes equal contribution, * denotes corresponding authors)

2026

Dynamic resilience: stress phenotypes impact opioid-taking behavior, brain activity, and gene expression.Tyner, E., Windisch, K. A., Zhang, X., Raman, S. A., Lu, C., Blendy, J. A.*Translational Psychiatry, 2026.
Perinatal morphine exposure induces chromatin and transcriptomic remodeling to alter immune and metabolic function.Ferrante, J. R.#, Du, Y.#, Zhang, X.#, Neice, J. D., Wang, W.*, Lu, C.*, Blendy, J. A.*Frontiers in Immunology 17, 1835359, 2026.
Microfluidic low-input profiling reveals lncRNA roles in disease.Catalano, J. A., Hsieh, Y.-P., Liu, Z., Li, G., Meana, J., Gonzalez-Maeso, J., Chen, Z. B., Lu, C.*bioRxiv, 2026.
Prenatal and postnatal effects of gestational immune activation on synaptic and neurodevelopmental pathways via epigenetic mechanisms.Zhu, B.#, Li, G.#, Saunders, J. M., Naler, L. B., Hadlock, T. M., Wang, C., García-Sastre, A., González-Maeso, J.*, Lu, C.*Translational Psychiatry 16 (1), 82, 2026.
A microreactor system for point-of-care viral genome sequencing.Hadlock, T. M., Neice, J. D., Li, S., Mor, S., Lu, C.*Biosensors and Bioelectronics, 118369, 2026.

2025

Sex-specific role of the 5-HT2A receptor in psilocybin-induced extinction of opioid reward.Jaster, A. M., Hadlock, T. M.#, Buzzi, B.#, Maltman, J. L., Silva, G. M., Saha, S., Koseli, E., Pondelick, A. M., Thakur, N., Zhang, X., Li, G., Ledesma-Corvi, S., Moore, K. N., Peterson, H. R., Fujita, B., Zylko, A. L., Lewis, M. R., Poklis, J. L., Halquist, M. S., Wolstenholme, J. T., Selley, D. E., Hamilton, P. J., Lu, C.*, Damaj, M. I.*, González-Maeso, J.*Nature Communications 16 (1), 10206, 2025.
Comprehensive multimodal and multiomic profiling reveals epigenetic and transcriptional reprogramming in lung tumors.Wu, P.#, Liu, Z.#, Zheng, L.#, Du, Y.#, Zhou, Z., Wang, W., Lu, C.*Communications Biology 8 (2025) 527.

2024

Towards an ai-driven cyber-physical system for closed-loop control of plant diseases.Silwal, A., Zhang, X. M., Hadlock, T., Neice, J., Haque, S., Kaundanya, A., Lu, C., et al.Proceedings of the AAAI Symposium Series 4 (1), 432-435, 2024.
Fusobacterium nucleatum infection modulates the transcriptome and epigenome of HCT116 colorectal cancer cells in an oxygen-dependent manner.Udayasuryan, B.#, Zhou, Z.#, Ahmad, R. N., Sobol, P., Deng, C., Nguyen, T. T. D., Kodikalla, S., Morrison, R., Goswami, I., Slade, D. J., Verbridge, S., Lu, C.*Communications Biology 7 (1), 551, 2024.
Antipsychotic-induced epigenomic reorganization in frontal cortex of individuals with schizophrenia.Zhu, B.#, Ainsworth, R. J.#, Wang, Z., Liu, Z., Sierra, S., Deng, C., Callado, L. F., Meana, J. J., Wang, W.*, Lu, C.*, Gonzalez-Maeso, J.*eLife 12 (2024) RP92393.
Epigenomic tomography for probing spatially defined chromatin state in the brain.Liu, Z.#, Deng, C.#, Zhou, Z., Xiao, Y., Jiang, S., Zhu, B., Naler, L., Jia, X., Yao, D., Lu, C.*Cell Reports Methods 4 (3), 2024.

2023

A Simplified Purpose-Built Microfluidic Platform for Nanopore Sequencing Library Preparation of Viral Samples.Hadlock, T., Neice, J., Mor, S., Lu, C.2023 AIChE Annual Meeting, 2023.
A Low-Input Microfluidic Method for Studying Genome-Wide Lncrna Binding Profiles.Catalano, J., Liu, Z., Hsieh, Y.-P., Lu, C.2023 AIChE Annual Meeting, 2023.
Droplet-based bisulfite sequencing for high-throughput profiling of single-cell DNA methylomes.Zhang, Q., Ma, S., Liu, Z., Zhu, B., Zhou, Z., Li, G., Meana, J., González-Maeso, J., Lu, C.*Nature Communications 14 (1), 4672, 2023.

2022

Epigenomic tomography for probing spatially-defined molecular state in the brain.Liu, Z.#, Deng, C.#, Zhou, Z., Xiao, Y., Jiang, S., Zhu, B., Naler, L. B., Jia, X., Yao, D., Lu, C.*bioRxiv, 2022.11.24.517865, 2022.
Subpopulation-specific machine learning prognosis for underrepresented patients with double prioritized bias correction.Afrose, S.#, Song, W.#, Nemeroff, C. B., Lu, C., Yao, D.*Communications medicine 2 (1), 111, 2022.
nMOWChIP-seq: low-input genome-wide mapping of non-histone targets.Liu, Z., Naler, L. B., Zhu, Y., Deng, C., Zhang, Q., Zhu, B., Zhou, Z., Sarma, M., Murray, A., Xie, H., Lu, C.*NAR genomics and bioinformatics 4 (2), lqac030, 2022.
Cell-type-specific epigenomic variations associated with BRCA1 mutation in pre-cancer human breast tissues.Hsieh, Y.-P.#, Naler, L. B.#, Ma, S., Lu, C.*NAR Genomics and Bioinformatics 4 (1), lqac006, 2022.
Epigenomic and transcriptomic analyses reveal differences between low-grade inflammation and severe exhaustion in LPS-challenged murine monocytes.Naler, L. B.#, Hsieh, Y.-P.#, Geng, Z., Zhou, Z., Li, L.*, Lu, C.*Communications Biology 5 (1), 102, 2022.

2021

Low-Input Technology Reveals Prolonged Epigenomic Alterations Following Single Exposure to a Psychedelic in Mice.Zhu, B., de la Fuente Revenga, M., Naler, L., Saunders, J. M., Zhou, Z., et al.2021 AIChE Annual Meeting, 2021.
Prolonged epigenomic and synaptic plasticity alterations following single exposure to a psychedelic in mice.de la Fuente Revenga, M., Zhu, B.#, Guevara, C. A.#, Naler, L. B., Saunders, J. M., Zhou, Z., Toneatti, R., Sierra, S., Wolstenholme, J. T., Beardsley, P. M., Huntley, G. W., Lu, C.*, Gonzalez-Maeso, J.*Cell reports 37 (3), 2021.
Native MOWChIP-seq: Genome-wide profiles of key protein bindings reveal functional differences among various brain regions.Liu, Z., Naler, L. B., Zhu, Y., Deng, C., Zhang, Q., Zhu, B., Zhou, Z., Sarma, M., Murray, A., Xie, H., Lu, C.*bioRxiv, 2021.07.11.451963, 2021.
Epigenomic and transcriptomic differences between low-grade and acute inflammation in LPS-induced murine immune cells.Naler, L. B.#, Hsieh, Y.-P.#, Geng, S., Zhou, Z., Li, L.*, Lu, C.*BioRxiv, 2021.03.28.437377, 2021.
Overcoming underrepresentation in clinical datasets for accurate subpopulation-specific prognosis.Afrose, S.#, Song, W.#, Nemeroff, C. B., Lu, C., Yao, D. D.*medRxiv, 2021.

2020

Multiplexed and ultralow-input chip-seq enabled by tagmentation-based indexing and facile microfluidics.Deng, C., Murphy, T., Zhang, Q., Naler, L., Xu, A., Lu, C.*Analytical chemistry 92 (20), 13661, 2020.
Microfluidic platform for next-generation sequencing library preparation with low-input samples.Murphy, T. W., Hsieh, Y.-P., Zhu, B., Naler, L. B., Lu, C.*Analytical chemistry 92 (3), 2519, 2020.
Phenylbutyrate facilitates homeostasis of non-resolving inflammatory macrophages.Rahtes, A., Pradhan, K., Sarma, M., Xie, H., Lu, C., Li, L.*Innate Immunity 26 (1), 62-72, 2020.

2019

MOWChIP-seq for low-input and multiplexed profiling of genome-wide histone modifications.Zhu, B.#, Hsieh, Y.-P.#, Murphy, T. W., Zhang, Q., Naler, L. B., Lu, C.*Nature Protocols 14 (12), 3366-3394, 2019.
Profiling Cell-Type-Specific Epigenomic Changes Associated with BRCA1 Mutation in Breast Tissues Using a Low-Input Microfluidic Technology.Hsieh, Y.-P., Naler, L., Zhang, X., Murphy, T., Li, R., Lu, C.2019 AIChE Annual Meeting, 2019.
Microfluidic epigenomic mapping technologies for precision medicine.Deng, C.#, Naler, L. B.#, Lu, C.*Lab on a Chip 19 (16), 2630-2650, 2019.
Interleukin-1β-induced IRAK1 ubiquitination is required for TH-GM-CSF cell differentiation in T cell-mediated inflammation.Hu, Y., Xu, F., Zhang, R., Legarda, D., Dai, J., Wang, D., Li, H., Zhang, Y., Xue, Q., et al.Journal of autoimmunity 102, 50-64, 2019.
Systems and methods for high throughput and parallel chromatin immunoprecipitation assays.Lu, C., Murphy, T.US Patent App. 16/163,702, 2019.
BRCA1 mutations attenuate super-enhancer function and chromatin looping in haploinsufficient human breast epithelial cells.Zhang, X., Wang, Y., Chiang, H. C., Hsieh, Y.-P., Lu, C., Park, B. H., Jatoi, I., Jin, V. X.*, Hu, Y.*, Li, R.*Breast cancer research 21 (1), 51, 2019.
A diffusion-based microfluidic device for single-cell RNA-seq.Sarma, M., Lee, J., Ma, S., Li, S., Lu, C.*Lab on a Chip 19 (7), 1247-1256, 2019.
On-chip manufacturing of synthetic proteins for point-of-care therapeutics.Murphy, T. W., Sheng, J., Naler, L. B., Feng, X., Lu, C.*Microsystems & nanoengineering 5 (1), 13, 2019.
Microfluidic MeDIP-seq for low-input methylomic analysis of mammary tumorigenesis in mice.Zhu, Y., Cao, Z., Lu, C.*Analyst 144 (6), 1904-1915, 2019.
Effects of culture condition on epigenomic profiles of brain tumor cells.Cox, M.#, Deng, C.#, Naler, L., Lu, C.*, Verbridge, S.*ACS biomaterials science & engineering 5 (3), 1544, 2019.

2018

Microfluidic low-input fluidized-bed enabled ChIP-seq device for automated and parallel analysis of histone modifications.Murphy, T. W., Hsieh, Y.-P., Ma, S., Zhu, Y., Lu, C.*Analytical chemistry 90 (12), 7666, 2018.
Low-input and multiplexed microfluidic assay reveals epigenomic variation across cerebellum and prefrontal cortex.Ma, S., Hsieh, Y.-P., Ma, J., Lu, C.*Science Advances 4 (4), eaar8187, 2018.
Microfluidics-based chromosome conformation capture (3C) technology for examining chromatin organization with a low quantity of cells.Sun, C., Lu, C.*Analytical chemistry 90 (6), 3714, 2018.
Cell-type-specific brain methylomes profiled via ultralow-input microfluidics.Ma, S., de la Fuente Revenga, M., Sun, Z., Sun, C., Murphy, T. W., Xie, H., Gonzalez-Maeso, J., Lu, C.*Nature biomedical engineering 2 (3), 183-194, 2018.

2017

Recent advances in the use of microfluidic technologies for single cell analysis.Murphy, T. W., Zhang, Q., Naler, L. B., Ma, S., Lu, C.*Analyst 143 (1), 60-80, 2017.
Microfluidic ChIP-Seq Device for Rapid and Parallel Analysis of Histone Modifications.Murphy, T., Ma, S., Lu, C.2017 AIChE Annual Meeting, 2017.
Microfluidic systems and methods for chromatin immunoprecipitation (ChIP).Lu, C., Cao, Z.US Patent 9,732,377, 2017.
Microfluidics for genome-wide studies involving next generation sequencing.Ma, S., Murphy, T. W., Lu, C.*Biomicrofluidics 11 (2), 2017.
Immunomagnetic separation of tumor initiating cells by screening two surface markers.Sun, C., Hsieh, Y.-P., Ma, S., Geng, S., Cao, Z., Li, L., Lu, C.*Scientific reports 7 (1), 40632, 2017.
Technical Innovation.Ma, S., Schroeder, B., Sun, C., Loufakis, D. N., Cao, Z., Sriranganathanb, N., Lu, C.

2016

Paramagnetic structures within a microfluidic channel for enhanced immunomagnetic isolation and surface patterning of cells.Sun, C., Hassanisaber, H., Yu, R., Ma, S., Verbridge, S. S., Lu, C.Scientific reports 6 (1), 29407, 2016.
Microfluidic Chromatin Immunoprecipitation for Analysis of Epigenomic Regulations.Zhu, Y., Lu, C.*Microfluidic Methods for Molecular Biology, 349-363, 2016.
Microfluidic methods for molecular biology.Lu, C., Verbridge, S. S.Springer, 2016.
RNA extraction from a mycobacterium under ultrahigh electric field intensity in a microfluidic device.Ma, S., Bryson, B. D., Sun, C., Fortune, S. M., Lu, C.*Analytical chemistry 88 (10), 5053, 2016.
A microfluidic device with integrated sonication and immunoprecipitation for sensitive epigenetic assays.Cao, Z., Lu, C.*Analytical chemistry 88 (3), 1965, 2016.

2015

A microfluidic device for epigenomic profiling using 100 cells.Cao, Z.#, Chen, C.#, He, B., Tan, K.*, Lu, C.*Nature methods 12, 959-962, 2015.
Optimal Design of Microfluidic Platforms for Diffusion-Based PCR for “One-Pot” Analysis of Cells.Crow, J., Achenie, L. E. K., Lu, C., Ma, S., Loufakis, D. N., Cao, Z., Chang, Y.Computer Aided Chemical Engineering 37, 1199-1204, 2015.
Quantitative Detection of Nucleocytoplasmic Transport of Native Proteins in Single Cells.Cao, Z., Lu, C.*Single Cell Protein Analysis: Methods and Protocols, 239-252, 2015.

2014

Intracellular tracking of single native molecules with electroporation-delivered quantum dots.Sun, C., Cao, Z., Wu, M., Lu, C.*Analytical chemistry 86 (22), 11403-11409, 2014.
Flow effects in the laser-induced thermal loading of optical traps and optofluidic devices.Del Rosal, B., Sun, C., Yan, Y., Mackenzie, M. D., Lu, C., Bettiol, A. A., Kar, A. K., et al.Optics Express 22 (20), 23938-23954, 2014.
Electroporation-based delivery of cell-penetrating peptide conjugates of peptide nucleic acids for antisense inhibition of intracellular bacteria.Ma, S., Schroeder, B., Sun, C., Loufakis, D. N., Cao, Z., Sriranganathan, N., Lu, C.*Integrative Biology 6 (10), 973-978, 2014.
Electroporation-delivered fluorescent protein biosensors for probing molecular activities in cells without genetic encoding.Sun, C., Ouyang, M., Cao, Z., Ma, S., Alqublan, H., Sriranganathan, N., Wang, Y., Lu, C.*Chemical Communications 50 (78), 11536-11539, 2014.
Diffusion-based microfluidic PCR for “one-pot” analysis of cells.Ma, S., Loufakis, D. N., Cao, Z., Chang, Y., Achenie, L. E. K., Lu, C.*Lab on a Chip 14 (16), 2905-2909, 2014.
Focusing of mammalian cells under an ultrahigh pH gradient created by unidirectional electropulsation in a confined microchamber.Loufakis, D. N., Cao, Z., Ma, S., Mittelman, D., Lu, C.*Chemical Science 5 (8), 3331-3337, 2014.
Detecting intracellular translocation of native proteins quantitatively at the single cell level.Cao, Z., Geng, S., Li, L., Lu, C.*Chemical Science 5 (6), 2530-2535, 2014.
MICROFLUIDIC ELECTROPORATION FOR DELIVERY OF CELL-PENETRATING PEPTIDE CONJUGATES OF PEPTIDE NUCLEIC ACIDS (PNA) FOR ANTISENSE INHIBITION OF INTRACELLULAR BACTERIA.Ma, S., Schroeder, B., Sun, C., Loufakis, D. N., Cao, Z., Sriranganathan, N., Lu, C.18th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2014), 2014.

2013

Microfluidic electroporation for cellular analysis and delivery.Geng, T., Lu, C.*Lab on a Chip 13 (19), 3803-3821, 2013.
Thermal loading in flow-through electroporation microfluidic devices.Del Rosal, B., Sun, C., Loufakis, D. N., Lu, C., Jaque, D.Lab on a Chip 13 (15), 3119-3127, 2013.

2012

Microfluidic Devices for Cellular Proteomic Studies.Zhan, Y., Lu, C.Microfluidic Technologies for Human Health, 161, 2012.
Droplet sorting based on the number of encapsulated particles using a solenoid valve.Cao, Z., Chen, F., Bao, N., He, H., Xu, P., Jana, S., Jung, S., Lian, H., Lu, C.*Lab on a Chip 13 (1), 171-178, 2012.
Characterizing osmotic lysis kinetics under microfluidic hydrodynamic focusing for erythrocyte fragility studies.Zhan, Y., Loufakis, D. N., Bao, N., Lu, C.*Lab on a Chip 12 (23), 5063-5068, 2012.
Genomic DNA extraction from cells by electroporation on an integrated microfluidic platform.Geng, T., Bao, N., Sriranganathan, N., Li, L., Lu, C.*Analytical chemistry 84 (21), 9632, 2012.
Release of intracellular proteins by electroporation with preserved cell viability.Zhan, Y., Sun, C., Cao, Z., Bao, N., Xing, J., Lu, C.*Analytical chemistry 84 (19), 8102-8105, 2012.
Gene delivery by microfluidic flow-through electroporation based on constant DC and AC field.Geng, T., Zhan, Y., Lu, C.2012 Annual International Conference of the IEEE Engineering in Medicine and …, 2012.
Low-frequency ac electroporation shows strong frequency dependence and yields comparable transfection results to dc electroporation.Zhan, Y., Cao, Z., Bao, N., Li, J., Wang, J., Geng, T., Lin, H., Lu, C.*Journal of controlled release 160 (3), 570-576, 2012.
Quantitative measurement of quantum dot uptake at the cell population level using microfluidic evanescent-wave-based flow cytometry.Wang, J., Zhan, Y., Bao, N., Lu, C.*Lab on a Chip 12 (8), 1441-1445, 2012.
Quantum dot (QD)-modified carbon tape electrodes for reproducible electrochemiluminescence (ECL) emission on a paper-based platform.Shi, C. G., Shan, X., Pan, Z. Q., Xu, J. J., Lu, C., Bao, N., Gu, H. Y.Analytical chemistry 84 (6), 3033-3038, 2012.
Single cell NF-κB dynamics observed under stimulant concentration gradient.Awwad, Y., Geng, T., Baldwin, A. S., Lu, C.*Analytical chemistry 84 (3), 1224, 2012.

2011

Chemical transfection of cells in picoliter aqueous droplets in fluorocarbon oil.Chen, F., Zhan, Y., Geng, T., Lian, H., Xu, P., Lu, C.*Analytical chemistry 83 (22), 8816-8820, 2011.
The Effect of Interleukin-1 (IL-1) Concentration on Single Cell NF-kappaB Activation in a Gradient-Generating Microfluidic Device.Awwad, Y. A.Virginia Tech, 2011.
Single-cell electrical lysis of erythrocytes detects deficiencies in the cytoskeletal protein network.Bao, N., Kodippili, G. C., Giger, K. M., Fowler, V. M., Low, P. S., Lu, C.*Lab on a Chip 11 (18), 3053-3056, 2011.
Histone modification analysis by chromatin immunoprecipitation from a low number of cells on a microfluidic platform.Geng, T., Bao, N., Litt, M. D., Glaros, T. G., Li, L., Lu, C.*Lab on a Chip 11 (17), 2842-2848, 2011.
Transfection of cells using flow-through electroporation based on constant voltage.Geng, T., Zhan, Y., Wang, J., Lu, C.*Nature protocols 6 (8), 1192-1208, 2011.

2010

Kinetics of NF-κB nucleocytoplasmic transport probed by single-cell screening without imaging.Wang, J., Fei, B., Zhan, Y., Geahlen, R. L., Lu, C.*Lab on a Chip 10 (21), 2911-2916, 2010.
Quantitative analysis of protein translocations by microfluidic total internal reflection fluorescence flow cytometry.Wang, J., Fei, B., Geahlen, R. L., Lu, C.*Lab on a Chip 10 (20), 2673-2679, 2010.
Electroporative flow cytometry.Lu, C., Wang, J., Bao, N., Geahlen, R. L.US Patent App. 12/716,974, 2010.
One-step extraction of subcellular proteins from eukaryotic cells.Zhan, Y., Martin, V. A., Geahlen, R. L., Lu, C.*Lab on a Chip 10 (16), 2046-2048, 2010.
Vortex-assisted DNA delivery.Wang, J., Zhan, Y., Ugaz, V. M., Lu, C.*Lab on a Chip 10 (16), 2057-2061, 2010.
Flow-through electroporation based on constant voltage for large-volume transfection of cells.Geng, T., Zhan, Y., Wang, H. Y., Witting, S. R., Cornetta, K. G., Lu, C.*Journal of Controlled Release 144 (1), 91-100, 2010.
Chemical cytometry: ultrasensitive analysis of single cells.Lu, C.(No Title), 2010.
Microfluidic electroporation of tumor and blood cells: observation of nucleus expansion and implications on selective analysis and purging of circulating tumor cells.Bao, N., Le, T. T., Cheng, J.-X., Lu, C.*Integrative biology 2 (2-3), 113-120, 2010.
Electroporative Flow Cytometry for Single‐Cell Analysis.Lu, C., Wang, J., Bao, N., Wang, H. Y.Chemical cytometry: ultrasensitive analysis of single cells, 125-142, 2010.
Electroporation-based selective extraction of subcellular proteins.Zhan, Y., Martin, V. A., Geahlen, R. L., Lu, C.14th International Conference on Miniaturized Systems for Chemistry and Life …, 2010.
Flow-through Electroporation for Transfection Based On Low-Frequency AC Voltage.Zhan, Y., Wang, J., Bao, N., Geng, T., Lu, C.14th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2010), 1550-1552, 2010.
A NOVEL CYTOMETRIC TOOL FOR STUDYING KINETICS OF NANOPARTICLE UPTAKE INTO CELLS.Wang, J., Lu, C.14th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2010), 256-258, 2010.
STUDYING NF-KAPPA B TRANSLOCATION BETWEEN NUCLEUS AND CYTOPLASM BY ELECTROPORATIVE FLOW CYTOMETRY.Wang, J., Fei, B., Zhan, Y., Geahlen, R. L., Lu, C.14th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2010), 1661-1663, 2010.

2009

ANYL 5-Microfluidic electroporative flow cytometry for studying single-cell biomechanics.Bao, N., Lu, C.*, Zhan, Y.ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 238, 2009.
ANYL 34-Microfluidic electroporation for high-throughput differentiation of intracellular materials at the single-cell level.Bao, N., Wang, J., Lu, C.*ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 238, 2009.
Electroporation of cells in microfluidic droplets.Zhan, Y., Wang, J., Bao, N., Lu, C.*Analytical chemistry 81 (5), 2027-2031, 2009.
Modulating DNA adsorption on silica beads using an electrical switch.Geng, T., Bao, N., Gall, O. Z., Lu, C.*Chemical communications 45 (7), 800-802, 2009.
Modulating DNA adsorption on silica beads in an electrically actuated microfluidic device.Geng, T., Bao, N., Gall, O. Z., Lu, C.2009 AIChE Annual Meeting, 09AIChE, 2009.
Cell motion in shear flow combined with Dean vortices strongly affects DNA transfer during flow-through electroporation.Wang, J., Zhan, Y., Ugaz, V. M., Lu, C.MicroTAS’09, 2009.

2008

Total internal reflection fluorescence flow cytometry.Wang, J., Bao, N., Paris, L. L., Geahlen, R. L., Lu, C.*Analytical chemistry 80 (24), 9840, 2008.
A microfluidic cell array with individually addressable culture chambers.Wang, H. Y., Bao, N., Lu, C.Biosensors and Bioelectronics 24 (4), 613-617, 2008.
Microfluidic electroporative flow cytometry for studying single-cell biomechanics.Bao, N., Zhan, Y., Lu, C.*Analytical Chemistry 80 (20), 7714-7719, 2008.
Microfluidic electroporation for selective release of intracellular molecules at the single‐cell level.Bao, N., Wang, J., Lu, C.*Electrophoresis 29 (14), 2939-2944, 2008.
Microfluidic electroporation for delivery of small molecules and genes into cells using a common DC power supply.Wang, H. Y., Lu, C.*Biotechnology and bioengineering 100 (3), 579-586, 2008.
Recent advances in electric analysis of cells in microfluidic systems.Bao, N., Wang, J., Lu, C.*Analytical and bioanalytical chemistry 391 (3), 933-942, 2008.
A microfluidic device for physical trapping and electrical lysis of bacterial cells.Bao, N., Lu, C.Applied Physics Letters 92 (21), 2008.
Microfluidic delivery of small molecules into mammalian cells based on hydrodynamic focusing.Wang, F., Wang, H., Wang, J., Wang, H. Y., Rummel, P. L., Garimella, S. V., Lu, C.Biotechnology and bioengineering 100 (1), 150-158, 2008.
Microfluidic CARS cytometry.Wang, H. W., Bao, N., Le, T. T., Lu, C., Cheng, J.-X.*Optics express 16 (8), 5782-5789, 2008.
Quantification of bacterial cells based on autofluorescence on a microfluidic platform.Bao, N., Jagadeesan, B., Bhunia, A. K., Yao, Y., Lu, C.Journal of Chromatography A 1181 (1-2), 153-158, 2008.
Detection of kinase translocation using microfluidic electroporative flow cytometry.Wang, J., Bao, N., Paris, L. L., Wang, H. Y., Geahlen, R. L., Lu, C.*Analytical chemistry 80 (4), 1087-1093, 2008.
A Microfluidic Device for Physical Extraction of Intracellular Proteins from Bacterial Cells.Bao, N., Lu, C.*The 2008 Annual Meeting, 2008.
Microfluidics-based lysis of bacteria and spores for detection and analysis.Bao, N., Lu, C.Principles of Bacterial Detection: Biosensors, Recognition Receptors and …, 2008.

2007

Microfluidic cell electroporation using a mechanical valve.Wang, J., Stine, M. J., Lu, C.*Analytical chemistry 79 (24), 9584-9587, 2007.
Determination of the Number of Bacteria Based on Autofluorescence on a Microfluidic Chip.Bao, N., Jagadeesan, B., Bhunia, A. K., Lu, C.The 2007 Annual Meeting, 2007.
Microfluidic Cell Fusion Under Constant Direct Current Voltage.Wang, J., Lu, C.The 2007 Annual Meeting, 2007.
Differential Release of Intracellular Molecules during Electrical Lysis Observed at the Single Cell Level.Bao, N., Wang, J., Lu, C.The 2007 Annual Meeting, 2007.
Single molecule λ-DNA stretching studied by microfluidics and single particle tracking.Wang, J., Lu, C.Journal of applied physics 102 (7), 2007.
Microfluidics-based electroporative delivery of small molecules and genes into cells under constant voltage.Wang, H. Y., Lu, C.*ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 234, 2007.
Fluidic device.Lu, C., Wang, H. Y., Wang, J.US Patent App. 11/583,535, 2007.
Rapid electrical lysis of bacterial cells in a microfluidic device.Wang, H. Y., Banada, P. P., Bhunia, A. K., Lu, C.Microchip-Based Assay Systems: Methods and Applications, 23-35, 2007.

2006

High‐throughput and real‐time study of single cell electroporation using microfluidics: Effects of medium osmolarity.Wang, H. Y., Lu, C.Biotechnology and bioengineering 95 (6), 1116-1125, 2006.
A microfluidic flow-through device for high throughput electrical lysis of bacterial cells based on continuous dc voltage.Wang, H. Y., Bhunia, A. K., Lu, C.Biosensors and Bioelectronics 22 (5), 582-588, 2006.
Microfluidic cell fusion under continuous direct current voltage.Wang, J., Lu, C.Applied Physics Letters 89 (23), 2006.
Electroporation of mammalian cells in a microfluidic channel with geometric variation.Wang, H. Y., Lu, C.*Analytical chemistry 78 (14), 5158-5164, 2006.
A nanoporous silicon membrane electrode assembly for on-chip micro fuel cell applications.Chu, K. L., Gold, S., Subramanian, V., Lu, C., Shannon, M. A., Masel, R. I.Journal of Microelectromechanical systems 15 (3), 671-677, 2006.
Delivery of Molecules and DNA into Mammalian Cells by Electroporation on a Microfluidic Device.Wang, H. Y., Mascarenhas, N., Kothari, S. A., Lu, C.The 2006 Annual Meeting, 2006.
Microfluidic chemical cytometry based on modulation of local field strength.Wang, H. Y., Lu, C.Chemical communications, 3528-3530, 2006.

2005

Microfluidic pretreatment of bacterial cells for analysis of intracellular contents.Wang, H. Y., Lu, C., Banada, P. P., Jagadeesan, B., Bhunia, A. K.Optical Sensors and Sensing Systems for Natural Resources and Food Safety …, 2005.
Integrated Cell Lysis and Electrophoresis-Based Immunoassay for Bacteria Detection on a Microfluidic Chip.Wang, H. Y., Jagadeesan, B., Bhunia, A. K., Lu, C.The 2005 Annual Meeting, 2005.
Separation of denatured proteins in free solution on a microchip based on differential binding of alkyl sulfates with different carbon chain lengths.Lu, C., Smith, A. E., Craighead, H. G.Chemical communications 41 (2), 183-185, 2005.
Continuous lysis of cells in a locally concentrated DC field on a microfluidic chip.Wang, H. Y., Banada, P. P., Bhunia, A. K., Lu, C.05AIChE: 2005 AIChE Annual Meeting and Fall Showcase, 2005.

2004

Acid loaded porous silicon as a proton exchange membrane for micro-fuel cells.Gold, S., Chu, K. L., Lu, C., Shannon, M. A., Masel, R. I.Journal of Power Sources 135 (1-2), 198-203, 2004.

2002

UHV, electrochemical NMR, and electrochemical studies of platinum/ruthenium fuel cell catalysts.Lu, C., Rice, C., Masel, R. I., Babu, P. K., Waszczuk, P., Kim, H. S., Oldfield, E., et al.The Journal of Physical Chemistry B 106 (37), 9581-9589, 2002.
UHV and electrochemical studies of CO and methanol adsorbed at platinum/ruthenium surfaces, and reference to fuel cell catalysis.Waszczuk, P., Lu, G. Q., Wieckowski, A., Lu, C., Rice, C., Masel, R. I.Electrochimica Acta 47 (22-23), 3637-3652, 2002.
Correlations between the Heat of Adsorption and the Position of the Center of the D-Band: Differences between Computation and Experiment.Lu, C., Lee, I. C., Masel, R. I., Wieckowski, A., Rice, C.The Journal of Physical Chemistry A 106 (13), 3084-3091, 2002.

2001

The Effect of Ruthenium on the Binding of CO, H2, and H2O on Pt(110).Lu, C., Masel, R. I.The Journal of Physical Chemistry B 105 (40), 9793-9797, 2001.
Chemistry of Methoxonium on (2× 1) Pt (110).Lu, C., Thomas, F. S., Masel, R. I.The Journal of Physical Chemistry B 105 (36), 8583-8590, 2001.
Evidence for a cation intermediate during methanol dehydration on Pt (110).Thomas, F., Lu, C., Lee, I. C., Chen, N. S., Masel, R. I.Catalysis letters 72 (3), 167-175, 2001.

2000

Catalytic oxidation of odorous organic acids.Ali, N., Lu, C., Masel, R.Catalysis today 62 (4), 347-353, 2000.